Targeting alpha7 nicotinic acetylcholine receptors in the treatment of schizophrenia.

@article{Hajs2010TargetingAN,
  title={Targeting alpha7 nicotinic acetylcholine receptors in the treatment of schizophrenia.},
  author={Mih{\'a}ly Haj{\'o}s and Bruce N. Rogers},
  journal={Current pharmaceutical design},
  year={2010},
  volume={16 5},
  pages={
          538-54
        }
}
The most abundant homomeric nicotinic acetylcholine receptors (nAChRs) in the mammalian brain are the pentameric alpha7 nAChRs which consist of five alpha7 subunits, and each subunit provides an orthosteric low affinity binding site for its endogenous ligand, acetylcholine. Distribution and high level expression of alpha7 nAChRs within the limbic circuitry, including the hippocampus and prefrontal cortical areas are in line with their involvement in various cognitive functions. Activation of… CONTINUE READING

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