Targeting adipose tissue in the treatment of obesity-associated diabetes

@article{Kusminski2016TargetingAT,
  title={Targeting adipose tissue in the treatment of obesity-associated diabetes},
  author={Christine M. Kusminski and Perry E Bickel and Phillip E Scherer},
  journal={Nature Reviews Drug Discovery},
  year={2016},
  volume={15},
  pages={639-660}
}
Adipose tissue regulates numerous physiological processes, and its dysfunction in obese humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 diabetes mellitus (T2DM). Although several US-approved treatments for obesity and T2DM exist, these are limited by adverse effects and a lack of effective long-term glucose control. In this Review, we provide an overview of the role of adipose tissue in metabolic homeostasis and assess emerging novel therapeutic… CONTINUE READING
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