Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels

Abstract

During ischemic stroke, neurons at risk are exposed to pathologically high levels of intracellular calcium (Ca++), initiating a fatal biochemical cascade. To protect these neurons, we have developed openers of large-conductance, Ca++-activated (maxi-K or BK) potassium channels, thereby augmenting an endogenous mechanism for regulating Ca++ entry and… (More)
DOI: 10.1038/86546

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