Targeting activity is required for SWI/SNF function in vivo and is accomplished through two partially redundant activator-interaction domains.

@article{Prochasson2003TargetingAI,
  title={Targeting activity is required for SWI/SNF function in vivo and is accomplished through two partially redundant activator-interaction domains.},
  author={Philippe Prochasson and Kristen E. Neely and Ahmed H.M. Hassan and Bing Nan Li and Jerry L. Workman},
  journal={Molecular cell},
  year={2003},
  volume={12 4},
  pages={983-90}
}
The SWI/SNF complex is required for the expression of many yeast genes. Previous studies have implicated DNA binding transcription activators in targeting SWI/SNF to UASs and promoters. To determine how activators interact with the complex and to examine the importance of these interactions, relative to other potential targeting mechanisms, for SWI/SNF function, we sought to identify and mutate the activator-interaction domains in the complex. Here we show that the N-terminal domain of Snf5 and… CONTINUE READING

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