Targeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia.

@article{Meyer2001TargetingAG,
  title={Targeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia.},
  author={Dan E. Meyer and Gary A. Kong and Mark W. Dewhirst and Michael R. Zalutsky and Ashutosh Chilkoti},
  journal={Cancer research},
  year={2001},
  volume={61 4},
  pages={1548-54}
}
Elastin-like polypeptides (ELPs) are biopolymers of the pentapeptide repeat Val-Pro-Gly-Xaa-Gly that undergo an inverse temperature phase transition. They are soluble in aqueous solutions below their transition temperature (T1) but hydrophobically collapse and aggregate at temperatures greater than T1. We hypothesized that ELPs conjugated to drugs would enable thermally targeted drug delivery to solid tumors if their T1 were between body temperature and the temperature in a locally heated… CONTINUE READING

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