Targeting a genetic defect: cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis.

  • Nico Derichs
  • Published 2013 in
    European respiratory review : an official journal…

Abstract

Cystic fibrosis (CF) is caused by genetic mutations that affect the cystic fibrosis transmembrane conductance regulator (CFTR) protein. These mutations can impact the synthesis and transfer of the CFTR protein to the apical membrane of epithelial cells, as well as influencing the gating or conductance of chloride and bicarbonate ions through the channel… (More)
DOI: 10.1183/09059180.00008412

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