Targeting WNT1-inducible signaling pathway protein 2 alters human breast cancer cell susceptibility to specific lysis through regulation of KLF-4 and miR-7 expression

@article{Akalay2015TargetingWS,
  title={Targeting WNT1-inducible signaling pathway protein 2 alters human breast cancer cell susceptibility to specific lysis through regulation of KLF-4 and miR-7 expression},
  author={Intissar Akalay and Tuan Zea Tan and Prasanna K. M. Kumar and Bassam Janji and Fathia Mami-Chouaib and C{\'e}cile Charpy and Philippe Vielh and Annette Kragh Larsen and Jean Paul Thiery and Mouhamad Sabbah and Salem Chouaib},
  journal={Oncogene},
  year={2015},
  volume={34},
  pages={2261-2271}
}
The molecular basis for the resistance of tumor cells to cell-mediated cytotoxicity remains poorly understood and thus poses a major challenge for cancer immunotherapy. The present study was designed to determine whether the WNT1-inducible signaling pathway protein 2 (WISP2, also referred to as CCN5), a key regulator of tumor cell plasticity, interferes with tumor susceptibility to cytotoxic T-lymphocyte (CTL)-mediated lysis. We found that silencing WISP2 signaling in human breast… CONTINUE READING
17 Citations
40 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Similar Papers

Loading similar papers…