Targeting WISP1 to sensitize esophageal squamous cell carcinoma to irradiation

  title={Targeting WISP1 to sensitize esophageal squamous cell carcinoma to irradiation},
  author={Hongfang Zhang and Honglei Luo and Zhaoyang Hu and Jin Peng and Zhenzhen Jiang and Tao Song and Bo Wu and Jing Yue and Rongjing Zhou and Ruifei Xie and Tian Chen and Shixiu Wu},
Radiotherapy is a primary treatment modality for esophageal squamous cell carcinoma (ESCC). However, most of patients benefited little from radiotherapy due to refractory radioresistance. We found that WISP1, a downstream target gene of Wnt/β-catenin pathway, was re-expressed in 67.3% of ESCC patients as an oncofetal gene. Expression of WISP1 predicted prognosis of ESCC patients treated with radiotherapy. Overall survival in WISP1-positive patients was significantly poorer than in WISP1… CONTINUE READING
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