Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection.

  title={Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection.},
  author={Nicholas S Heaton and Natasha P Moshkina and Romain Fenouil and Thomas J. Gardner and Sebastian Aguirre and Priya S. Shah and Nan Zhao and Lara Manganaro and Judd F. Hultquist and Justine Noel and David M Sachs and Jennifer R Hamilton and Paul E. Leon and Amit Chawdury and Shashank Tripathi and Camilla Melegari and Laura Campisi and Rong Hai and Giorgi Metreveli and Andrea V. Gamarnik and Adolfo Garc{\'i}a-Sastre and Benjamin D. Greenbaum and Viviana A Simon and Ana Fern{\'a}ndez-Sesma and Nevan J. Krogan and Lubbertus C. F. Mulder and Harm van Bakel and Domenico Tortorella and Jack Taunton and P. Palese and Ivan Marazzi},
  volume={44 1},
Viruses are obligate parasites and thus require the machinery of the host cell to replicate. Inhibition of host factors co-opted during active infection is a strategy hosts use to suppress viral replication and a potential pan-antiviral therapy. To define the cellular proteins and processes required for a virus during infection is thus crucial to understanding the mechanisms of virally induced disease. In this report, we generated fully infectious tagged influenza viruses and used infection… CONTINUE READING
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