Targeting Type Iγ Phosphatidylinositol Phosphate Kinase Inhibits Breast Cancer Metastasis

@inproceedings{Chen2015TargetingTI,
  title={Targeting Type Iγ Phosphatidylinositol Phosphate Kinase Inhibits Breast Cancer Metastasis},
  author={Chunhua Chen and Xiangling Wang and Xunhao Xiong and Qingbo Liu and Yan Huang and Qingwen Xu and Jinghua Hu and Gaoxiang Ge and Kun Ling},
  booktitle={Oncogene},
  year={2015}
}
Most deaths from breast cancer are caused by metastasis, a complex behavior of cancer cells involving migration, invasion, survival and microenvironment manipulation. Type Iγ phosphatidylinositol phosphate kinase (PIPKIγ) regulates focal adhesion assembly and its phosphorylation at Y639 is critical for cell migration induced by EGF. However, the role of this lipid kinase in tumor metastasis remains unclear. Here we report that PIPKIγ is vital for breast cancer metastasis. Y639 of PIPKIγ can be… CONTINUE READING
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