Targeting Tumor-Associated Fibroblasts for Therapeutic Delivery in Desmoplastic Tumors.

@article{Miao2017TargetingTF,
  title={Targeting Tumor-Associated Fibroblasts for Therapeutic Delivery in Desmoplastic Tumors.},
  author={Lei Miao and Qi Liu and Chu-hsiung Lin and Cong Shuang Luo and Yuhua Wang and Lina Liu and Weiyan Yin and Shihao Hu and William Y. Kim and Leaf Huang},
  journal={Cancer research},
  year={2017},
  volume={77 3},
  pages={
          719-731
        }
}
The off-target distribution of anticancer nanoparticles to fibroblasts creates a barrier to the effective treatment of desmoplastic tumors. However, we hypothesized that this nanoparticle detriment might be exploited to target the expression of secreted cytotoxic proteins from tumor-associated fibroblasts (TAF) as an anticancer strategy. In addressing this hypothesis, plasmids encoding the secretable TNF-related factor sTRAIL were loaded into lipid-coated protamine DNA complexes and… CONTINUE READING
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