Targeting TR4 nuclear receptor with antagonist bexarotene increases docetaxel sensitivity to better suppress the metastatic castration-resistant prostate cancer progression

@article{Hu2019TargetingTN,
  title={Targeting TR4 nuclear receptor with antagonist bexarotene increases docetaxel sensitivity to better suppress the metastatic castration-resistant prostate cancer progression},
  author={Linyi Hu and Yin Sun and Jie Luo and Xiang He and Meihua Ye and Gonghui Li and Yiqun Zhang and Jian Bai and Dahong Zhang and Chawnshang Chang},
  journal={Oncogene},
  year={2019},
  volume={39},
  pages={1891 - 1903}
}
Prostate cancer (PCa) is the second leading cause of cancer death in men in America, and there are no curative options for metastatic castration-resistant prostate cancer (mCRPC). Docetaxel (DTX) has been used as a standard chemotherapy for the mCRPC. However, resistance to DTX is a significant clinical problem as half of patients fail to respond to therapy. The TR4 nuclear receptor has been reported to play an important role in PCa progression, however, its linkage to the DTX resistance… Expand
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