Targeting TLR2 attenuates pulmonary inflammation and fibrosis by reversion of suppressive immune microenvironment.

@article{Yang2009TargetingTA,
  title={Targeting TLR2 attenuates pulmonary inflammation and fibrosis by reversion of suppressive immune microenvironment.},
  author={Hong-zhen Yang and Bing Cui and Han-zhi Liu and Zhi-Rong Chen and Hui-Min Yan and Fang Hua and Zhuo-wei Hu},
  journal={Journal of immunology},
  year={2009},
  volume={182 1},
  pages={692-702}
}
Pulmonary fibrosis is a consequence of chronic lung injury and is associated with a high mortality. Despite the pathogenesis of pulmonary fibrosis remaining as an enigma, immune responses play a critical role in the deregulation of wound healing process after lung injury, which leads to fibrosis. Accumulating evidence argues the rationales for current treatments of pulmonary fibrosis using immunosuppressive agents such as corticosteroids. In this study, we report that bleomycin (BLM), a well… CONTINUE READING
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