Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells.

@article{Koo2017TargetingTK,
  title={Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells.},
  author={C Y Koo and Caterina Giacomini and Marta Reyes-Corral and Yolanda Olmos and Ignatius A. Tavares and Charles M. Marson and Spiros Linardopoulos and Andrew N J Tutt and Jonathan D. Morris},
  journal={Molecular cancer therapeutics},
  year={2017},
  volume={16 11},
  pages={
          2410-2421
        }
}
Thousand-and-one amino acid kinases (TAOK) 1 and 2 are activated catalytically during mitosis and can contribute to mitotic cell rounding and spindle positioning. Here, we characterize a compound that inhibits TAOK1 and TAOK2 activity with IC50 values of 11 to 15 nmol/L, is ATP-competitive, and targets these kinases selectively. TAOK inhibition or depletion… CONTINUE READING