Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease.

@article{Flynn2015TargetingSB,
  title={Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease.},
  author={Ryan P Flynn and Jessica L. Allen and Leo Luznik and Kelli P A Macdonald and Katelyn Paz and Kylie Anne Alexander and Ante Vulic and Jing Du and Angela Panoskaltsis-Mortari and Patricia A. Taylor and Jonathan C Poe and Jonathan S. Serody and William J. Murphy and Geoffrey R Hill and Ivan P Maillard and John Koreth and Corey S Cutler and Robert J. Soiffer and Joseph H Antin and Jerome Ritz and Nelson J Chao and Raphael Clynes and Stefanie Sarantopoulos and Bruce R Blazar},
  journal={Blood},
  year={2015},
  volume={125 26},
  pages={4085-94}
}
Novel therapies for chronic graft-versus-host disease (cGVHD) are needed. Aberrant B-cell activation has been demonstrated in mice and humans with cGVHD. Having previously found that human cGVHD B cells are activated and primed for survival, we sought to further evaluate the role of the spleen tyrosine kinase (Syk) in cGVHD in multiple murine models and human peripheral blood cells. In a murine model of multiorgan system, nonsclerodermatous disease with bronchiolitis obliterans where cGVHD is… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 16 times over the past 90 days. VIEW TWEETS
25 Citations
37 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 37 references

B cells from patients with chronic GVHD signal via the AKTdriven survival and metabolic fitness pathway.Biol Blood Marrow Transplant

  • JL Allen, J Wooten, M Fore
  • FLYNN et al BLOOD,
  • 2015

B cells from patients with chronic GVHD signal via the AKT - driven survival and metabolic fitness pathway

  • JL Allen, J Wooten, M Fore
  • Biol Blood Marrow Transplant
  • 2012

Similar Papers

Loading similar papers…