Targeting Survivin in Cancer: Novel Drug Development Approaches

  title={Targeting Survivin in Cancer: Novel Drug Development Approaches},
  author={Bernd Groner and Astrid Weiss},
Survivin is a well-established target in experimental cancer therapy. The molecule is over-expressed in most human tumors, but hardly detectable in normal tissues. Multiple functions in different subcellular compartments have been assigned. It participates in the control of cell division, apoptosis, the cellular stress response, and also in the regulation of cell migration and metastasis. Survivin expression has been recognized as a biomarker: high expression indicates an unfavorable prognosis… CONTINUE READING
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