Targeting STAT3 in cancer: how successful are we?

  title={Targeting STAT3 in cancer: how successful are we?},
  author={P. K. Yue and James Turkson},
  journal={Expert opinion on investigational drugs},
  volume={18 1},
BACKGROUND Aberrant activation of the signal transducer and activator of transcription (STAT)3 occurs in many human tumors. Moreover, studies utilizing genetic and pharmacological approaches to modulate constitutive STAT3 activity have provided compelling evidence for the critical role of aberrant STAT3 activity in malignant transformation and tumor progression, and thereby validated STAT3 as a novel cancer drug target. OBJECTIVE This review is intended to be a full coverage of the efforts to… CONTINUE READING


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