Targeting SRC and epidermal growth factor receptor in colorectal cancer: rationale and progress into the clinic.

@article{Kopetz2007TargetingSA,
  title={Targeting SRC and epidermal growth factor receptor in colorectal cancer: rationale and progress into the clinic.},
  author={Scott Kopetz},
  journal={Gastrointestinal cancer research : GCR},
  year={2007},
  volume={1 4 Suppl 2},
  pages={S37-41}
}
  • Scott Kopetz
  • Published 2007 in Gastrointestinal cancer research : GCR
Src is a non-receptor protein tyrosine kinase that affects proliferation, angiogenesis, differentiation, migration, invasion, and regulation of apoptosis in colorectal cancer cells. Src activation is a frequent early epigenetic event in colorectal cancer, and is progressively increased in metastatic tumors as compared with primary tumors. Src has also been implicated as a component of epidermal growth factor receptor (EGFR) signal transduction. In particular, Src, as a mediator of receptor… CONTINUE READING

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Src continues aging: current and future clinical directions.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2007

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