Targeting SOD1 reduces experimental non–small-cell lung cancer.

@article{Glasauer2014TargetingSR,
  title={Targeting SOD1 reduces experimental non–small-cell lung cancer.},
  author={Andrea Glasauer and Laura A. Sena and Lauren P. Diebold and Andrew P. Mazar and Navdeep S Chandel},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 1},
  pages={
          117-28
        }
}
Approximately 85% of lung cancers are non–small-cell lung cancers (NSCLCs), which are often diagnosed at an advanced stage and associated with poor prognosis. Currently, there are very few therapies available for NSCLCs due to the recalcitrant nature of this cancer. Mutations that activate the small GTPase KRAS are found in 20% to 30% of NSCLCs. Here, we report that inhibition of superoxide dismutase 1 (SOD1) by the small molecule ATN-224 induced cell death in various NSCLC cells, including… CONTINUE READING

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The landscape of somatic copy-number alteration across human cancers

  • R Beroukhim
  • Nature
  • 2010
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