Targeting Regulatory T Cells to Treat Patients With Systemic Lupus Erythematosus

@inproceedings{Mizui2018TargetingRT,
  title={Targeting Regulatory T Cells to Treat Patients With Systemic Lupus Erythematosus},
  author={Masayuki Mizui and George C Tsokos},
  booktitle={Front. Immunol.},
  year={2018}
}
Regulatory T cells (Tregs) are central in integration and maintenance of immune homeostasis. Since breakdown of self-tolerance is a major culprit in the pathogenesis of systemic lupus erythematosus (SLE), restoration of the immune tolerance through the manipulation of Tregs can be exploited to treat patients with SLE. New information has revealed that Tregs besides their role in suppressing the immune response are important in tissue protection and regeneration. Expansion of Tregs with low-dose… CONTINUE READING
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