Targeting RNA decay with 2',5' oligoadenylate-antisense in respiratory syncytial virus-infected cells.

@article{Cirino1997TargetingRD,
  title={Targeting RNA decay with 2',5' oligoadenylate-antisense in respiratory syncytial virus-infected cells.},
  author={Nick Mario Cirino and Guibin Li and Wuhan Xiao and Paul F. Torrence and Robert H Silverman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 5},
  pages={
          1937-42
        }
}
Treatment of human cells with 2',5' oligoadenylate covalently linked to antisense (2-5A-antisense) results in the selective cleavage of targeted RNA species by 2-5A-dependent RNase L. Here we show that 2-5A-antisense containing stabilizing modifications at both termini are effective in suppressing the replication of respiratory syncytial virus (RSV) in human tracheal epithelial cells. The affinity of 2-5A-antisense for different regions in the RSV M2 and L mRNAs was predicted from a computer… CONTINUE READING
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