Targeting RGD recognizing integrins: drug development, biomaterial research, tumor imaging and targeting.

@article{Meyer2006TargetingRR,
  title={Targeting RGD recognizing integrins: drug development, biomaterial research, tumor imaging and targeting.},
  author={Arnd Meyer and J{\"o}rg Auernheimer and Armin Modlinger and Horst Kessler},
  journal={Current pharmaceutical design},
  year={2006},
  volume={12 22},
  pages={
          2723-47
        }
}
Integrins constitute an important class of cell adhesion receptors responsible not only for cell-matrix adhesion but also for signaling bidirectionally across the membrane. Integrins are involved in many biological processes such as angiogenesis, thrombosis, inflammation, osteoporosis and cancer. Integrins thus play a key role in many severe human diseases. In this review we will describe recent research and development of RGD-containing integrin ligands for medical applications including drug… CONTINUE READING
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