Targeting RAS signaling pathways in juvenile myelomonocytic leukemia.

  title={Targeting RAS signaling pathways in juvenile myelomonocytic leukemia.},
  author={Christian Flotho and Christian Kratz and Charlotte Marie Niemeyer},
  journal={Current drug targets},
  volume={8 6},
The RAS proteins function as fundamental signaling switches that control normal cell growth and differentiation. Deregulated activation of RAS-dependent signaling pathways constitutes a potent mechanism of malignant cell transformation. Juvenile myelomonocytic leukemia (JMML) is a rapidly fatal myeloproliferative disorder of early childhood for which no effective treatment other than hematopoietic stem cell transplantation is currently available. Many aspects of JMML pathobiology are linked to… CONTINUE READING


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