Targeting RAGE Signaling in Inflammatory Disease.

  title={Targeting RAGE Signaling in Inflammatory Disease.},
  author={Barry I. Hudson and Marc E. Lippman},
  journal={Annual review of medicine},
The receptor for advanced glycation end-products (RAGE) is a multiligand pattern recognition receptor implicated in diverse chronic inflammatory states. RAGE binds and mediates the cellular response to a range of damage-associated molecular pattern molecules (DAMPs) including AGEs, HMGB1, S100s, and DNA. RAGE can also act as an innate immune sensor of microbial pathogen-associated molecular pattern molecules (PAMPs) including bacterial endotoxin, respiratory viruses, and microbial DNA. RAGE is… CONTINUE READING