Targeting Pediatric Cancer Stem Cells with Oncolytic Virotherapy

  title={Targeting Pediatric Cancer Stem Cells with Oncolytic Virotherapy},
  author={Gregory K Friedman and Kevin A. Cassady and Elizabeth Ann Beierle and James M Markert and George Yancey Gillespie},
  booktitle={Pediatric Research},
Cancer stem cells (CSCs), also termed “cancer-initiating cells” or “cancer progenitor cells,” which have the ability to self-renew, proliferate, and maintain the neoplastic clone, have recently been discovered in a wide variety of pediatric tumors. These CSCs are thought to be responsible for tumorigenesis and tumor maintenance, aggressiveness, and recurrence due to inherent resistance to current treatment modalities such as chemotherapy and radiation. Oncolytic virotherapy offers a novel… CONTINUE READING
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