Targeting PPARγ Signaling Cascade for the Prevention and Treatment of Prostate Cancer

@inproceedings{Sikka2012TargetingPS,
  title={Targeting PPARγ Signaling Cascade for the Prevention and Treatment of Prostate Cancer},
  author={Sakshi Sikka and Luxi Chen and Gautam Sethi and Alan Prem Kumar},
  booktitle={PPAR research},
  year={2012}
}
The peroxisome proliferator-activated receptor-gamma (PPARγ) is a member of the hormone-activated nuclear receptor superfamily. PPARγ can be activated by a diverse group of agents, such as endogenous polyunsaturated fatty acids, 15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)), and thiazolidinedione (TZD) drugs. PPARγ induces antiproliferative, antiangiogenic, and prodifferentiation pathways in several tissue types, thus making it a highly useful target for downregulation of carcinogenesis… CONTINUE READING
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