Targeting PI3 kinase/AKT/mTOR signaling in cancer.

  title={Targeting PI3 kinase/AKT/mTOR signaling in cancer.},
  author={Karen E Sheppard and Kathryn M. Kinross and Benjamin E. Solomon and Richard B Pearson and Wayne A Phillips},
  journal={Critical reviews in oncogenesis},
  volume={17 1},
The phosphatidylinositol 3 kinase (PI3K) pathway is one of the major pathways modulating cell growth, proliferation, metabolism, survival, and angiogenesis. Hyperactivation of this pathway is one of the most frequent occurrences in human cancer and is thus an obvious target for treatment of this disease. Currently there are 26 novel compounds targeting the PI3K pathway being assessed in more than 150 cancer-related clinical trials. Although this pathway is involved in many vital biologic… CONTINUE READING