Targeting P-selectin by gallium-68-labeled fucoidan positron emission tomography for noninvasive characterization of vulnerable plaques: correlation with in vivo 17.6T MRI.

@article{Li2014TargetingPB,
  title={Targeting P-selectin by gallium-68-labeled fucoidan positron emission tomography for noninvasive characterization of vulnerable plaques: correlation with in vivo 17.6T MRI.},
  author={Xiang Li and Wolfgang R. Bauer and Ina Israel and Michael C. Kreissl and Johannes Weirather and Dominik Richter and Elisabeth Bauer and Volker Herold and Peter M. Jakob and Andreas K. Buck and Stefan Frantz and Samuel S Samnick},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2014},
  volume={34 8},
  pages={1661-7}
}
OBJECTIVE Nuclear imaging of active plaques still remains challenging. Advanced atherosclerotic plaques have a strong expression of P-selectin by the endothelium overlying active atherosclerotic plaques, but not on the endothelium overlying inactive fibrous plaques. We proposed a new approach for noninvasive in vivo characterization of P-selectin on active plaques based on (68)Ga-Fucoidan, which is a polysaccharidic ligand of P-selectin with a nanomolar affinity. APPROACH AND RESULTS (68)Ga… CONTINUE READING