Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer

@inproceedings{Syed2017TargetingPI,
  title={Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer},
  author={Safiulla Basha Syed and Hemant Arya and I-Hsuan Fu and T I Yeh and Latha Periyasamy and H P Hsieh and Mohane Selvaraj Coumar},
  booktitle={Scientific Reports},
  year={2017}
}
P-glycoprotein (P-gp) is a drug transporter that effluxes chemotherapeutic drugs and is implicated in the development of resistance of cancer cells to chemotherapeutic drugs. To date, no drug has been approved to inhibit P-gp and restore chemotherapy efficacy. Moreover, majority of the reported inhibitors have high molecular weight and complex structures… CONTINUE READING