Targeting P‐selectin glycoprotein ligand‐1/P‐selectin interactions as a novel therapy for metabolic syndrome

  title={Targeting P‐selectin glycoprotein ligand‐1/P‐selectin interactions as a novel therapy for metabolic syndrome},
  author={M. Patel and David Miranda-Nieves and J. Chen and C. Haller and E. Chaikof},
  journal={Translational Research},
  • M. Patel, David Miranda-Nieves, +2 authors E. Chaikof
  • Published 2017
  • Biology, Medicine
  • Translational Research
  • &NA; Obesity‐induced insulin resistance and metabolic syndrome continue to pose an important public health challenge worldwide as they significantly increase the risk of type 2 diabetes and atherosclerotic cardiovascular disease. Advances in the pathophysiologic understanding of this process has identified that chronic inflammation plays a pivotal role. In this regard, given that both animal models and human studies have demonstrated that the interaction of P‐selectin glycoprotein ligand‐1… CONTINUE READING
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