Targeting Oliguria Reversal in Goal-Directed Hemodynamic Management Does Not Reduce Renal Dysfunction in Perioperative and Critically Ill Patients: A Systematic Review and Meta-Analysis

  title={Targeting Oliguria Reversal in Goal-Directed Hemodynamic Management Does Not Reduce Renal Dysfunction in Perioperative and Critically Ill Patients: A Systematic Review and Meta-Analysis},
  author={Mohamud Egal and Nicole Stephanie Erler and Hilde R. H. de Geus and Jasper van Bommel and Arie Bastiaan Johan Groeneveld},
  journal={Anesthesia \& Analgesia},
BACKGROUND:We investigated whether resuscitation protocols to achieve and maintain urine output above a predefined threshold—including oliguria reversal as a target––prevent acute renal failure (ARF). METHODS:We performed a systematic review and meta-analysis using studies found by searching MEDLINE, EMBASE, and references in relevant reviews and articles. We included all studies that compared “conventional fluid management” (CFM) with “goal-directed therapy” (GDT) using cardiac output, urine… 

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