Targeting Nur77 translocation.

  title={Targeting Nur77 translocation.},
  author={Xiaokun Zhang},
  journal={Expert opinion on therapeutic targets},
  volume={11 1},
  • Xiaokun Zhang
  • Published 2007 in Expert opinion on therapeutic targets
The ultimate growth of a tumour depends on not only the rate of tumour cell proliferation, but also the rate of tumour cell death (apoptosis). Nur77 (also known as TR3 or NGFI-B), an orphan member of the nuclear receptor superfamily, controls both survival and death of cancer cells. A wealth of recent experimental data demonstrates that the Nur77 activities are regulated through its subcellular localisation. In the nucleus, Nur77 functions as an oncogenic survival factor, promoting cancer cell… CONTINUE READING
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