Targeting Nonsquamous Nonsmall Cell Lung Cancer via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates.

@article{Wilson2016TargetingNN,
  title={Targeting Nonsquamous Nonsmall Cell Lung Cancer via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates.},
  author={Mike R. Wilson and Zhanjun Hou and Si Qiang Yang and Lisa Marie Polin and Juiwanna Kushner and K Ian White and Jenny Y. Huang and M. Rohith Anath Ratnam and Aleem Gangjee and Larry H. Matherly},
  journal={Molecular pharmacology},
  year={2016},
  volume={89 4},
  pages={
          425-34
        }
}
Pemetrexed (PMX) is a 5-substituted pyrrolo[2,3-d]pyrimidine antifolate used for therapy of nonsquamous nonsmall cell lung cancer (NS-NSCLC). PMX is transported by the reduced folate carrier (RFC) and proton-coupled folate transporter (PCFT). Unlike RFC, PCFT is active at acidic pH levels characterizing the tumor microenvironment. By real-time reverse-transcription polymerase chain reaction (RT-PCR) and immunohistochemistry, PCFT transcripts and proteins were detected in primary NS-NSCLC… CONTINUE READING
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