Targeting Netrin-1 in glioblastoma stem-like cells inhibits growth, invasion, and angiogenesis

@article{Sanvoranart2016TargetingNI,
  title={Targeting Netrin-1 in glioblastoma stem-like cells inhibits growth, invasion, and angiogenesis},
  author={Tanwarat Sanvoranart and Aungkura Supokawej and Pakpoom Kheolamai and Yaowalak U-pratya and Niphon Poungvarin and Sith Sathornsumetee and Surapol Issaragrisil},
  journal={Tumor Biology},
  year={2016},
  volume={37},
  pages={14949-14960}
}
Glioblastoma (GBM) is an aggressive malignant brain tumor that still lacks effective therapy. Glioblastoma stem cells (GBM-SCs) were identified to contribute to aggressive phenotypes and poor clinical outcomes for GBM. Netrin-1, an axon guidance molecule, has been found in several tumors in adults. However, the role of Netrin-1 in GBM-SCs remains largely unknown. In this study, CD133-positive U251 GBM cells were used as a putative GBM-SC population to identify the functions of Netrin-1. Using… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 58 references

Similar Papers

Loading similar papers…