Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo.

@article{Babetto2010TargetingNT,
  title={Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo.},
  author={Elisabetta Babetto and Bogdan Beirowski and Lucie Janeckova and Rosalind Brown and Jonathan Gilley and Derek Thomson and Richard R Ribchester and Michael P. Coleman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 40},
  pages={13291-304}
}
Axon and synapse degeneration are common components of many neurodegenerative diseases, and their rescue is essential for effective neuroprotection. The chimeric Wallerian degeneration slow protein (Wld(S)) protects axons dose dependently, but its mechanism is still elusive. We recently showed that Wld(S) acts at a non-nuclear location and is present in axons. This and other recent reports support a model in which Wld(S) protects by extranuclear redistribution of its nuclear NMNAT1 portion… CONTINUE READING
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