Targeting NF-κB-mediated inflammatory pathways in cisplatin-resistant NSCLC.
@article{Ryan2019TargetingNI, title={Targeting NF-$\kappa$B-mediated inflammatory pathways in cisplatin-resistant NSCLC.}, author={Sarah-Louise Ryan and Sam Beard and Martin P. Barr and Kazou Umezawa and Susan Heavey and Peter Godwin and Steven G. Gray and David Cormican and Stephen P. Finn and Kathy Gately and Anthony Davies and Erik W. Thompson and Derek J Richard and Kenneth J. O'Byrne and Mark N. Adams and Anne-Marie Baird}, journal={Lung cancer}, year={2019}, volume={135}, pages={ 217-227 } }
8 Citations
Identification of Proteins Deregulated by Platinum-Based Chemotherapy as Novel Biomarkers and Therapeutic Targets in Non-Small Cell Lung Cancer
- BiologyFrontiers in Oncology
- 2021
This study identified novel biomarkers and/or druggable proteins from deregulated protein networks within non-oncogene driven disease that are involved in the cellular response to cisplatin in NSCLC.
Defining COMMD4 as an anti-cancer therapeutic target and prognostic factor in non-small cell lung cancer
- Biology, MedicineBritish Journal of Cancer
- 2020
Investigating the prognostic and therapeutic potential of the copper-metabolism-domain-protein, COMMD4, in non-small cell lung cancers indicated that it may function as a prognostic factor and a potential therapeutic target for NSCLC, as its depletion induces cancer cell death.
Exosomal ERp44 derived from ER-stressed cells strengthens cisplatin resistance of nasopharyngeal carcinoma
- BiologyBMC cancer
- 2021
The data suggested that exosomal ERp44 derived from ER-stressed NPC cells took an inevitable role in NPC chemoresistance and might act as a treatment target.
H3K27me3 conditions chemotolerance in triple-negative breast cancer.
- Biology, MedicineNature genetics
- 2022
By monitoring epigenomes, transcriptomes and lineages with single-cell resolution, it is shown that the repressive histone mark H3K27me3 (trimethylation of histone H3 at lysine 27) regulates cell fate at the onset of chemotherapy, which highlights how chromatin landscapes shape the potential of cancer cells to respond to initial therapy.
Understanding Lung Carcinogenesis from a Morphostatic Perspective: Prevention and Therapeutic Potential of Phytochemicals for Targeting Cancer Stem Cells
- BiologyInternational journal of molecular sciences
- 2021
A comprehensive overview of how normal lung tissue operates and relate it with lung carcinogenesis to redefine better targets for lung cancer stem cells is provided and it is proposed that lung carcinomas should be treated differently based on their respective cellular origins.
Macrophages Reduce the Sensitivity of Osteosarcoma to Neoadjuvant Chemotherapy Drugs by Secreting Interleukin-1 Beta.
- Medicine, BiologyCancer letters
- 2020
New tricks of old drugs: Repurposing non-chemo drugs and dietary phytochemicals as adjuvants in anti-tumor therapies.
- Biology, MedicineJournal of controlled release : official journal of the Controlled Release Society
- 2020
RSF1 in cancer: interactions and functions
- BiologyCancer cell international
- 2021
The functional domains of RSF1 are summarized, the overexpression status ofRSF1 and SNF2H in cancer based on the TCGA and GTE X databases, the cancer-related functions of RSf1 in interacting with H2Aub, HDAC1, CENP-A, PLK1, ATM, C ENP-S, SNF 2H, HB X and NF-κB are summarized and the potential clinical value is summarized.
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It is revealed that hypoxia-improved cisplatin chemoresistance of NSCLC cells by regulated MDR1 and MRP1 expression via HIF1α/ROS pathway is reversed by LW6, suggesting that LW6 may act as effective sensitizer in chemotherapy forNSCLC.