Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition.

@article{Cea2011TargetingNS,
  title={Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition.},
  author={Michele Cea and Antonia Cagnetta and Mariateresa T. Fulciniti and Yt Tai and Teru Hideshima and Dharminder Chauhan and Aldo M Roccaro and Antonio Sacco and Teresa Calimeri and Francesca Cottini and Jana Jakubikova and Sun-Young Kong and Franco Patrone and Alessio Nencioni and Marco Gobbi and Paul Truman Richardson and Nikhil C. Munshi and Kenneth C. Anderson},
  journal={Blood},
  year={2011},
  volume={120 17},
  pages={
          3519-29
        }
}
Malignant cells have a higher nicotinamide adenine dinucleotide (NAD(+)) turnover rate than normal cells, making this biosynthetic pathway an attractive target for cancer treatment. Here we investigated the biologic role of a rate-limiting enzyme involved in NAD(+) synthesis, Nampt, in multiple myeloma (MM). Nampt-specific chemical inhibitor FK866 triggered cytotoxicity in MM cell lines and patient MM cells, but not normal donor as well as MM patients PBMCs. Importantly, FK866 in a dose… CONTINUE READING

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