Targeting N-methyl-D-aspartate receptors for treatment of neuropathic pain.

  title={Targeting N-methyl-D-aspartate receptors for treatment of neuropathic pain.},
  author={Hong-Yi Zhou and Shao-rui Chen and H. I. Pan},
  journal={Expert review of clinical pharmacology},
  volume={4 3},
Neuropathic pain remains a major clinical problem and a therapeutic challenge because existing analgesics are often ineffective and can cause serious side effects. Increased N-methyl-d-aspartate receptor (NMDAR) activity contributes to central sensitization in certain types of neuropathic pain. NMDAR antagonists can reduce hyperalgesia and allodynia in animal models of neuropathic pain induced by nerve injury and diabetic neuropathy. Clinically used NMDAR antagonists, such as ketamine and… CONTINUE READING


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