Targeting Mcl-1 for the therapy of cancer.

  title={Targeting Mcl-1 for the therapy of cancer.},
  author={Bridget A. Quinn and Rupesh Dash and Belal M Azab and Siddik Sarkar and Swadesh Kumar Das and Sachin Kumar and Regina A. Oyesanya and Santanu Dasgupta and Paul Dent and Steven Grant and Mohamed Rahmani and David T. Curiel and Igor P. Dmitriev and Michael Hedvat and Jun Koh Wei and Bainan Wu and John L. Stebbins and John C. Reed and Maurizio Pellecchia and Devanand Sarkar and Paul B Fisher},
  journal={Expert opinion on investigational drugs},
  volume={20 10},
INTRODUCTION Human cancers are genetically and epigenetically heterogeneous and have the capacity to commandeer a variety of cellular processes to aid in their survival, growth and resistance to therapy. One strategy is to overexpress proteins that suppress apoptosis, such as the Bcl-2 family protein Mcl-1. The Mcl-1 protein plays a pivotal role in protecting cells from apoptosis and is overexpressed in a variety of human cancers. AREAS COVERED Targeting Mcl-1 for extinction in these cancers… CONTINUE READING
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