Targeting MAPK (Ras/ERK) and PI3K/Akt pathways in pituitary tumorigenesis.

@article{akir2009TargetingM,
  title={Targeting MAPK (Ras/ERK) and PI3K/Akt pathways in pituitary tumorigenesis.},
  author={M. Cihan Çakir and Ashley B. Grossman},
  journal={Expert opinion on therapeutic targets},
  year={2009},
  volume={13 9},
  pages={1121-34}
}
BACKGROUND Pituitary adenomas are common intracranial neoplasms, comprising 10 - 15% of all brain tumors. Data from autopsy studies suggest that pituitary adenomas develop in 17 - 25% of the population. Nevertheless, the pathogenesis of sporadic pituitary tumors still remains obscure. OBJECTIVE In this review, the roles of MAPK (mainly Ras/extracellular signal-regulated protein kinase (ERK)) and PI3K/Akt signaling pathways in pituitary tumorigenesis are summarised. METHODS A full data… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…