Targeting MAPK (Ras/ERK) and PI3K/Akt pathways in pituitary tumorigenesis.

  title={Targeting MAPK (Ras/ERK) and PI3K/Akt pathways in pituitary tumorigenesis.},
  author={M. Cihan Çakir and Ashley B. Grossman},
  journal={Expert opinion on therapeutic targets},
  volume={13 9},
BACKGROUND Pituitary adenomas are common intracranial neoplasms, comprising 10 - 15% of all brain tumors. Data from autopsy studies suggest that pituitary adenomas develop in 17 - 25% of the population. Nevertheless, the pathogenesis of sporadic pituitary tumors still remains obscure. OBJECTIVE In this review, the roles of MAPK (mainly Ras/extracellular signal-regulated protein kinase (ERK)) and PI3K/Akt signaling pathways in pituitary tumorigenesis are summarised. METHODS A full data… CONTINUE READING
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