Targeting Lyn inhibits tumor growth and metastasis in Ewing's sarcoma.

  title={Targeting Lyn inhibits tumor growth and metastasis in Ewing's sarcoma.},
  author={Hui Jie Guan and Zhichao Zhou and Gary E. Gallick and S F Jia and Jaime L Morales and Anil Sood and Seth J Corey and Eugenie S Kleinerman},
  journal={Molecular cancer therapeutics},
  volume={7 7},
Src family tyrosine kinases (SFK) play an important role in growth and metastasis of many types of human malignancies. However, their significance in Ewing's sarcoma remains to be elucidated. The purpose of this study was to evaluate the role of Lyn, one member of the SFK, in Ewing's sarcoma growth and metastasis and to determine whether a SFK inhibitor can induce Ewing's tumor regression. Lyn was expressed and activated in TC71, A4573, and SK-ES human Ewing's sarcoma cells. Lyn expression was… CONTINUE READING
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