Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis

@inproceedings{Papageorgis2015TargetingIA,
  title={Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis},
  author={Panagiotis Papageorgis and Sait R. Ozturk and Arthur W Lambert and Christiana Neophytou and Alexandros Tzatsos and Chen Khuan Wong and Sam Thiagalingam and Andreas I. Constantinou},
  booktitle={Breast Cancer Research},
  year={2015}
}
Basal-like breast cancer (BLBC) is an aggressive subtype often characterized by distant metastasis, poor patient prognosis, and limited treatment options. Therefore, the discovery of alternative targets to restrain its metastatic potential is urgently needed. In this study, we aimed to identify novel genes that drive metastasis of BLBC and to elucidate the underlying mechanisms of action. An unbiased approach using gene expression profiling of a BLBC progression model and in silico leveraging… CONTINUE READING
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