Targeting IL-8 signalling to inhibit breast cancer stem cell activity.

  title={Targeting IL-8 signalling to inhibit breast cancer stem cell activity.},
  author={Jagdeep K. Singh and Bruno M. Sim{\~o}es and Robert B. Clarke and Nigel J. Bundred},
  journal={Expert opinion on therapeutic targets},
  volume={17 11},
Although survival from breast cancer has improved significantly over the past 20 years, disease recurrence remains a significant clinical problem. The concept of stem-like cells in cancer has been gaining currency over the last decade or so, since evidence for stem cell activity in human leukaemia and solid tumours, including breast cancer, was first published. Evidence indicates that this sub-population of cells, known as cancer stem-like cells (CSCs), is responsible for driving tumour… CONTINUE READING
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