Targeting IL-17 and TH17 cells in chronic inflammation

@article{Miossec2012TargetingIA,
  title={Targeting IL-17 and TH17 cells in chronic inflammation},
  author={Pierre Miossec and Jay K Kolls},
  journal={Nature Reviews Drug Discovery},
  year={2012},
  volume={11},
  pages={763-776}
}
The key role of interleukin-17 (IL-17) and T helper 17 (TH17) cells in tissue inflammation, autoimmunity and host defence led to the experimental targeting of these molecules in mouse models of diseases as well as in clinical settings. Moreover, the demonstration that IL-17 and TH17 cells contribute to local and systemic aspects of disease pathogenesis, as well as the finding that the IL-17–TH17 cell pathway is regulated by IL-23, prompted the identification of inhibitors. These inhibitors… CONTINUE READING

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 382 CITATIONS, ESTIMATED 50% COVERAGE

Interleukin-17A Promotes Lung Tumor Progression through Neutrophil Attraction to Tumor Sites and Mediating Resistance to PD-1 Blockade.

  • Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma

  • Science Translational Medicine
  • 2015
VIEW 6 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

IL-17 and IL-17R: an auspicious therapeutic target for psoriatic disease.

  • Actas dermo-sifiliograficas
  • 2014
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2013
2019

CITATION STATISTICS

  • 28 Highly Influenced Citations

  • Averaged 49 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 104 REFERENCES

Interleukin 17 as a novel predictor of vascular function in rheumatoid arthritis

W. Marder
  • Ann . Rheum . Dis .
  • 2012

Bone marrow ‐ and synovium ‐ derived mesenchymal cells promote Th ‐ 17 cells through caspase ‐ 1 activation : contribution to rheumatoid arthritis chronicity

A. Eljaafari
  • Arthritis Rheum .
  • 2011