Targeting Histone Deacetylases in Diseases: Where Are We?

  title={Targeting Histone Deacetylases in Diseases: Where Are We?},
  author={Rosaria Benedetti and Mariarosaria Conte and Lucia Altucci},
  journal={Antioxidants & redox signaling},
  volume={23 1},
SIGNIFICANCE Epigenetic inactivation of pivotal genes involved in cell growth is a hallmark of human pathologies, in particular cancer. Histone acetylation balance obtained through opposing actions of histone deacetylases (HDACs) and histone acetyltransferases is one epigenetic mechanism controlling gene expression and is, thus, associated with disease etiology and progression. Interfering pharmacologically with HDAC activity can correct abnormalities in cell proliferation, migration… CONTINUE READING


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