Targeting HLA class I expression to increase tumor immunogenicity.

@article{Campo2012TargetingHC,
  title={Targeting HLA class I expression to increase tumor immunogenicity.},
  author={Ana B del Campo and Javier Carretero and Natalia Aptsiauri and Federico Garrido},
  journal={Tissue antigens},
  year={2012},
  volume={79 3},
  pages={147-54}
}
The dynamic interaction between the host immune system and growing cancer has been of central interest to the field of tumor immunology over the past years. Recognition of tumor-associated antigens (TAA) by self-HLA (human leukocyte antigen) class I-restricted CD8+ T cells is a main feature in the detection and destruction of malignant cells. The discovery and molecular characterization of TAA has changed the field of cancer treatment and introduced a new era of cancer immunotherapy aimed at… CONTINUE READING

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