Targeting HIF1α eliminates cancer stem cells in hematological malignancies.

  title={Targeting HIF1α eliminates cancer stem cells in hematological malignancies.},
  author={Youxiang Wang and Yan Liu and S. Nur Hidayah Malek and Pan Zheng and Yang Liu},
  journal={Cell stem cell},
  volume={8 4},
Molecular targeting of cancer stem cells (CSCs) has therapeutic potential for efficient treatment of cancer, although relatively few specific targets have been identified so far. Hypoxia-inducible factor (HIF) was recently shown to regulate the tumorigenic capacity of glioma stem cells under hypoxic conditions. Surprisingly, we found that, under normoxia, HIF1α signaling was selectively activated in the stem cells of mouse lymphoma and human acute myeloid leukemia (AML). HIF1a shRNA and HIF… CONTINUE READING
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