Targeting HIF function: the debate continues.

  title={Targeting HIF function: the debate continues.},
  author={Paresh Vyas},
  volume={124 24},
in fact lead to more tumor toxicity in vivo? Similarly, might it reduce the effector functions of various immune effectors when used in combination with mAbs? For these answers, we eagerly await the results of the upcoming trials and further in vitro experimentation. Despite these unresolved questions, this article provides exciting new data and insight into the biology of the PI3K signaling pathway in CLL cells, which will enable the development of more effective drugs for the treatment of… CONTINUE READING
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