Targeting HIF-1 for cancer therapy

  title={Targeting HIF-1 for cancer therapy},
  author={Gregg L Semenza},
  journal={Nature Reviews Cancer},
Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose metabolism and invasion. Intratumoral hypoxia and genetic alterations can lead to HIF-1α overexpression, which has been associated with increased patient mortality in several cancer types. In preclinical studies, inhibition of HIF-1 activity has marked effects on tumour growth. Efforts are underway to identify inhibitors… CONTINUE READING
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