Targeting HDACs: A Promising Therapy for Alzheimer's Disease

@inproceedings{Xu2011TargetingHA,
  title={Targeting HDACs: A Promising Therapy for Alzheimer's Disease},
  author={Ke Xu and Xue-Ling Dai and Han-Chang Huang and Zhao-feng Jiang},
  booktitle={Oxidative medicine and cellular longevity},
  year={2011}
}
Epigenetic modifications like DNA methylation and histone acetylation play an important role in a wide range of brain disorders. Histone deacetylases (HDACs) regulate the homeostasis of histone acetylation. Histone deacetylase inhibitors, which initially were used as anticancer drugs, are recently suggested to act as neuroprotectors by enhancing synaptic plasticity and learning and memory in a wide range of neurodegenerative and psychiatric disorders, such as Alzheimer's disease (AD) and… CONTINUE READING

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